Bacterial Persistence in Animal Tissues

Phosphorus Compounds in Animal Tissues

The concept that nucleic acids are intimately associated with fundamental cellular processes has gained considerable favor within the last few years. This can undoubtedly be attributed to the researches of Caspersson and his associates. Caspersson, with the aid of ultraviolet spectrophotometry, has been able to measure the nucleic acids in various parts of the cell under a variety of experiment...

Deoxyribosyl compounds in animal tissues.

Several types of deoxyribosyl compounds have been found in the acidsoluble fraction of normal and malignant tissues (l-8). In 1955 Potter and Schlesinger (1) reported the isolation of deoxynucleoside mono-, di-, and triphosphates from extracts of calf thymus. More recently LePage (7) reported the isolation of deoxyadenosine triphosphate from a tumor. Schneider (2), using a microbiological assay...

Drug residues in animal tissues.

Bacterial persistence: a winning strategy?

It has long been known that antibiotic treatment will not completely kill off a bacteria population. For many species a small fraction of bacteria is not sensitive to antibiotics. These bacteria are said to persist. Recently it has been shown that persistence is not a permanent state and that in fact a bacterium can switch back and forth between persistent and non persistent states. We introduc...

Bacterial persistence by RNA endonucleases.

Bacteria form persisters, individual cells that are highly tolerant to different types of antibiotics. Persister cells are genetically identical to nontolerant kin but have entered a dormant state in which they are recalcitrant to the killing activity of the antibiotics. The molecular mechanisms underlying bacterial persistence are unknown. Here, we show that the ubiquitous Lon (Long Form Filam...